Despite that cities are being built for people and by people, by 2024 there are no straightfor-ward legit guidelines that would prescribe the steps of developing a sustainable neighborhood. Numerous neighborhoods, districts, and cities cannot provide safe and clean environments with healthy social interaction, fulfill the demand for health, child, and educational facilities, guarantee the right for adequate equal housing, and attract the public for economic prosperity and development. This study aims to propose a framework with which the practitioners can determine the necessity of the neighborhood for Sustainable Urban Transformation (SUT), hence influencing the development of sustainable neighborhoods, cities, and communities. In the study, Design Science Research Methodology (DSRM) was followed to create a framework. Preferred urban model tangible characteristics together with the main measurable indicators of the neighborhood have been combined into a framework. It has been categorized by social, economic, and environmental sectors and refers to Sustainable Development Goals (SDGs). The framework was reviewed by experts, which resulted in a gap in the research. Further ap-plication of the framework to the existing central neighborhood in Istanbul determined the necessity of sustainable urban transformation.